ࡱ> LNKq` 0 bjbjqPqP .2::.......B $ Bj IKKKKKKhx jK.K..`b..II:,..]  7jI Iv0S : ]] .,g^LKK BBB& BBB& BBB......  HYPERLINK "javascript:AL_get(this,%20'jour',%20'Aliment%20Pharmacol%20Ther.');" Aliment Pharmacol Ther. 2000 Sep;14(9):1133-9. HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3046&itool=AbstractPlus-def&uid=10971229&db=pubmed&url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=2000&volume=14&issue=9&spage=1133" \t "_blank"  INCLUDEPICTURE "http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-images-pubmed_linkout_FREE_fulltext.gif" \* MERGEFORMATINET   HYPERLINK "javascript:PopUpMenu2_Set(Menu10971229);" \t "_self" Links Bioavailability of four ursodeoxycholic acid preparations.  HYPERLINK "http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Williams%20CN%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus" Williams CN,  HYPERLINK "http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Al-Knawy%20B%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus" Al-Knawy B,  HYPERLINK "http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Blanchard%20W%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus" Blanchard W. Division of Gastroenterology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. gicnw@qe2-hsc.ns.ca BACKGROUND: Ursodeoxycholic acid (UDCA) is the drug of choice for treating primary biliary cirrhosis and dissolving cholesterol gallstones. OBJECTIVES: The objective of this study was to compare the bioavailability of four commercially available ursodeoxycholic acid formulations in standardized doses. METHODS: Twenty-four healthy subjects were studied in groups of four, and received each of the different UDCA preparations in random order, with a 1-week washout or more in-between. Serum UDCA levels were determined for a 6-h period. The mean area under the curve (AUC), Cmax and Tmax were determined for each drug formulation, and the results compared. Dose proportionality was determined using the Canadian Ursofalk tablet using either 250 mg, 500 mg or 750 mg dosing. The intraparticipant variability was assessed by asking each participant to repeat the last drug that they took the second time, 1 week later. RESULTS: The mean AUC was 68.99 micromol/1.6 h-1 for the USA UDCA tablet, 59.34 micromol/1.6 h-1 for the Canadian UDCA tablet, 55.55 micromol/1.6 h-1 for Ursolvan capsules, and 46.66 micromol/1.6 h-1 for Actigall capsules. The mean Cmax values were 24.29, 17.85, 16.63 and 413.32 nmol/mL, respectively. The mean Tmax was 1.82, 2.3, 2.79 and 3.39 h, respectively. Linear aggression analysis assessing the direct proportionality of AUC on the dose for the Canadian UDCA tablet gave an estimate of 0.063 + 0.0164 (standard error, P-value=0.0117), e.g. if the dose increases from 250 mg to 500 mg, the serum ursodeoxycholic acid increases by 250 x 0.063=15.75. There was excellent reproducibility for the AUC for the North American tablets (0.97, 0.88) compared to the two capsules (0.32, 0.15). CONCLUSIONS: The significantly higher AUC and Cmax and shorter Tmax for the Canadian Ursofalk tablets compared to the UDCA capsule preparations supports better bioavailability. PMID: 10971229 [PubMed - indexed for MEDLINE] Related articles  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/12503774?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=1&log$=relatedarticles&logdbfrom=pubmed" Pharmacokinetics and bioavailability of four modified-release ursodeoxycholic acid preparations for once-a-day administration. Int J Clin Pharmacol Res. 2002; 22(2):37-45. [Int J Clin Pharmacol Res. 2002]  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/7596954?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=2&log$=relatedarticles&logdbfrom=pubmed" Bioavailability study of a new, sinking, enteric-coated ursodeoxycholic acid formulation. Pharmacol Res. 1995 Feb; 31(2):115-9. [Pharmacol Res. 1995]  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/17692728?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed" Bioavailability of two oral suspension and two oral tablet formulations of acyclovir 400 mg: two single-dose, open-label, randomized, two-period crossover comparisons in healthy Mexican adult subjects. Clin Ther. 2007 Jun; 29(6):1146-52. [Clin Ther. 2007]  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/18612911?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=4&log$=relatedarticles&logdbfrom=pubmed" Preparation, characterization, and bioavailability of ursodeoxycholic acid-phospholipid complex in vivo. Drug Dev Ind Pharm. 2008 Jul; 34(7):708-18. [Drug Dev Ind Pharm. 2008]  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/10655778?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed" Review[Basic studies on the utility of ursodeoxycholic acid derivatives for clinical medicine] Yakugaku Zasshi. 2000 Jan; 120(1):1-15. [Yakugaku Zasshi. 2000]  HYPERLINK "http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed_reviews&uid=10971229&ordinalpos=1&log$=relatedarticles&logdbfrom=pubmed" See reviews... |  HYPERLINK "http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=10971229&ordinalpos=1&log$=relatedarticles&logdbfrom=pubmed" See all... Patient Drug Information  HYPERLINK "http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=meds&log$=drug_bottom_one&part=a699047" Ursodiol (Actigall ) Ursodiol is used to dissolve gallstones in patients who do not want surgery or cannot have surgery to remove gallstones. Ursodiol is also used to prevent the formation of gallstones in overweight patients who are losing ... 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